Semax
Semax is a synthetic heptapeptide derived from the ACTH (adrenocorticotropic hormone) fragment 4–7. Developed in Russia, it has been studied extensively for cognitive enhancement, neuroprotection, and stroke recovery. It is approved as a medication in Russia and Ukraine.
Quick facts
- Half-life
- ~1–2 minutes (rapidly metabolised)
- Administration
- Nasal spray / Subcutaneous injection
- Primary use
- Cognitive enhancement, neuroprotection
How it works
Semax increases the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), supporting neuroplasticity and neuronal survival. It also modulates dopaminergic and serotonergic systems, contributing to its cognitive and mood-enhancing effects.
Reported benefits
- Enhanced focus, memory, and mental clarity
- Neuroprotective effects — studied for stroke recovery
- Increased BDNF and NGF expression
- Mood improvement and reduced mental fatigue
Typical dosing protocol
Dosing
200–900 mcg per day via nasal spray, typically split into 2–3 doses
Cycle length
2–4 weeks, with breaks of equal length
Dosing information is for educational reference only. Individual needs vary. Always consult a healthcare professional.
Safety & considerations
Generally well-tolerated in clinical studies. Not approved for human use in the UK. Approved as a medication in Russia. May cause mild irritability or overstimulation at high doses. Consult a healthcare professional before use.
Important: All content is for informational purposes only. Not medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.