Melanotan II
Melanotan II (MT-II) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). Originally developed as a potential sunless tanning agent, it also produces significant effects on sexual arousal and appetite suppression. PT-141 (Bremelanotide) was derived from MT-II.
Quick facts
- Half-life
- ~1 hour
- Administration
- Subcutaneous injection / Nasal spray
- Primary use
- Skin tanning, sexual function, appetite suppression
How it works
Melanotan II is a non-selective melanocortin receptor agonist, activating MC1R (skin pigmentation), MC3R and MC4R (sexual function, appetite, and energy balance). Its broad receptor activity produces multiple simultaneous effects.
Reported benefits
- Increased skin pigmentation (tanning) with or without UV exposure
- Enhanced sexual arousal and libido
- Appetite suppression and potential fat loss support
- Studied for erectile dysfunction and female sexual dysfunction
Typical dosing protocol
Dosing
0.25–1 mg subcutaneously; start at the lowest dose to assess tolerance. Nasal spray: 1–2 sprays as needed
Cycle length
Loading phase: daily for 1–2 weeks. Maintenance: 2–3x per week
Dosing information is for educational reference only. Individual needs vary. Always consult a healthcare professional.
Safety & considerations
Significant side effect profile: nausea, facial flushing, spontaneous erections, darkening of moles. Concerns exist around mole changes and melanoma risk with prolonged use. Not approved for human use in the UK. Consult a healthcare professional before use.
Important: All content is for informational purposes only. Not medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.