Kisspeptin-10
Kisspeptin-10 is a naturally occurring neuropeptide and the shortest active fragment of the kisspeptin family. It plays a central role in regulating the hypothalamic-pituitary-gonadal (HPG) axis, stimulating the release of GnRH, LH, and FSH. It is studied for reproductive disorders, hypogonadism, and libido.
Quick facts
- Half-life
- ~28 minutes
- Administration
- Subcutaneous injection / IV
- Primary use
- Reproductive health, LH/FSH stimulation, libido
How it works
Kisspeptin-10 binds to the KISS1R receptor on GnRH neurons in the hypothalamus, triggering a cascade that stimulates LH and FSH release from the pituitary. This makes it a master regulator of the reproductive hormone axis.
Reported benefits
- Stimulation of LH and FSH — supports natural testosterone production
- Studied for hypogonadism and fertility treatment
- Enhanced libido and sexual motivation via central pathways
- Potential use in post-cycle therapy (PCT) protocols
Typical dosing protocol
Dosing
50–100 mcg subcutaneously, 1–2x daily; or pulsatile dosing to mimic natural GnRH rhythm
Cycle length
4–8 weeks
Dosing information is for educational reference only. Individual needs vary. Always consult a healthcare professional.
Safety & considerations
Limited long-term human data outside of clinical fertility research. Not approved for general human use in the UK. Consult a healthcare professional — particularly relevant for those with hormone-sensitive conditions.
Important: All content is for informational purposes only. Not medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.