NAD+
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for energy metabolism and DNA repair. Levels decline significantly with age. Injectable NAD+ and its precursors (NMN, NR) are widely studied for anti-aging, cognitive, and metabolic benefits.
Quick facts
- Half-life
- ~1–2 hours (IV); variable subcutaneous
- Administration
- Subcutaneous injection / IV infusion / Oral (NMN/NR precursors)
- Primary use
- Cellular energy, longevity, neuroprotection
How it works
NAD+ is a critical cofactor for sirtuins (longevity-associated proteins) and PARP enzymes (DNA repair). It powers the mitochondrial electron transport chain and is essential for converting nutrients into cellular energy (ATP). Restoring declining NAD+ levels is hypothesised to slow aspects of biological ageing.
Reported benefits
- Improved cellular energy production and mitochondrial function
- Enhanced DNA repair via PARP enzyme activation
- Sirtuin activation — linked to longevity pathways
- Studied for neuroprotection, addiction recovery, and metabolic health
Typical dosing protocol
Dosing
Subcutaneous: 100–500 mg per day. IV: 250–1000 mg over several hours. Oral precursors (NMN): 250–1000 mg/day
Cycle length
Ongoing supplementation or periodic IV courses (e.g. 5–10 days)
Dosing information is for educational reference only. Individual needs vary. Always consult a healthcare professional.
Safety & considerations
IV NAD+ commonly causes flushing, nausea, and chest tightness — must be administered slowly. Subcutaneous injection is generally better tolerated. Not a licensed medicine in the UK. Consult a healthcare professional before use.
Tags
Important: All content is for informational purposes only. Not medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.