MOTS-c
MOTS-c is a mitochondria-derived peptide encoded within the mitochondrial genome — making it unique among research peptides. It regulates metabolic homeostasis, improves insulin sensitivity, and has been linked to longevity in animal models. Levels decline with age.
Quick facts
- Half-life
- ~1–2 hours
- Administration
- Subcutaneous injection
- Primary use
- Metabolic regulation, longevity, exercise performance
How it works
MOTS-c translocates to the cell nucleus in response to metabolic stress, where it regulates gene expression related to glucose metabolism and the folate cycle. It activates AMPK (a key energy-sensing enzyme) and promotes mitochondrial function.
Reported benefits
- Improved insulin sensitivity and glucose regulation
- Enhanced exercise performance and endurance
- AMPK activation — linked to longevity and metabolic health
- Anti-obesity effects observed in animal models
Typical dosing protocol
Dosing
5–10 mg subcutaneously, 3–5x per week
Cycle length
8–12 weeks
Dosing information is for educational reference only. Individual needs vary. Always consult a healthcare professional.
Safety & considerations
Limited human clinical data. Most research is from animal studies. Not approved for human use in the UK. Consult a healthcare professional before use.
Tags
Important: All content is for informational purposes only. Not medical advice. Always consult a qualified healthcare professional before starting any peptide protocol.